Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

Soft Tissue Sarcoma: FDG-PET/CT Defines Treatment Responders, Non-Responders

The diagnosing, staging and monitoring of cancer benefits from early response assessment. This includes patients with high-grade soft tissue sarcoma (STS), malignant tumors, which develop from fat, muscles, nerves, joints, blood vessels, bones and deep skin tissues. Until recently, oncologists typically had to wait months to see if treatment for this rare, and often deadly, disease was effective. PET/CT has changed that scenerio. Researchers now can assess a patients response or lack of response to treatment within one week of completing the first chemotherapy treatment. This is good news for both physicians and patients; physicians can make quicker, more efficient and complete treatment evaluations and alterations which may mean a better quality of life for many sarcoma patients. Another plus for U.S. based facilities is that Medicare coverage for STS was just added for initial treatment strategy.

Nuclear Medicine 2020: What Will the Landscape Look Like?

What does the future hold for nuclear medicine? Molecular Imaging Insight asked two nuclear medicine expertsMarkus Schwaiger, MD, chairman, Department of Nuclear Medicine and professor of nuclear medicine, at the Technical Universtiy of Munich in Germany and Liselotte Hjgaard, MD, DMSc, professor in medicine and technology, University of Copenhagen, and director, department of clinical physiology, nuclear medicine and PET at Rigshospitalet in Copenhagen, Denmarkto share their vision of nuclear medicine in 2020. How do their visions compare to each other, and to yours?

Evidence-based Medicine Across the Globe: The Successes & Challenges of Multinational Imaging Trials

Although evidence-based medicine has been the focus of work by many healthcare researchers, molecular imaging and nuclear medicine has received scant attention in this arena. 

Building the Business Case for Molecular Imaging

Molecular imaging is poised to make greater inroads into clinical practice in the next decade. Clinical evidence supporting broader use of PET/CT continues to mount, and the U.S. Centers for Medicare and Medicaid Services (CMS) recently issued a national coverage decision expanding Medicare reimbursement to 11 cancers.

NOPR Revisited

The design and subsequent implementation of NOPR followed a novel concept (coverage with evidence development) that mandates the development of evidence prior to CMS (Centers for Medicare & Medicaid Services) reimbursement for services.

Looking at Coronary Artery Disease from the Inside Out

Molecular Imaging Insight visits pioneers across the country to determine how molecular imaging is improving detection, risk stratification and treatment of coronary artery disease.

Molecular Imaging Meets Cardiac Stem Cell Therapy

As researchers continue to explore the role of stem cell therapy in cardiac medicine, molecular imaging will take center stage. Thats because transplanted cells must be tracked and monitored in vivo. Here is a closer look at various clinical trials focused on the potential of cardiac stem cell therapies that offer a better understanding of how various molecular imaging modalities will contribute to and measure the eventual clinical utility of cardiac stem cell-based therapies.

Building Awareness: Spreading the Word on Molecular Imaging

In an era that is becoming more focused on the need for developing evidence-based and personalized medicine, molecular imaging provides a detailed look into human physiology and disease at the cellular and molecular level.