Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

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Imaging Addiction: Could PET & MR End Cocaine Abuse?

Cocaine addiction can ruin a person physically and financially, and with an estimated 1.4 million cocaine users in the U.S., thousands will become trapped by their habit. While previous research on the drug and its addictive potential were observational and subjective, imaging is reshaping how we see addiction—and how it will be treated.

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Amyloid Imaging: Now Covered By CMS, With Major Caveats

On the heels of the final decision from CMS regarding coverage for amyloid imaging in late September, Molecular Imaging Insight talked with amyloid PET imaging expert Peter Herscovitch, MD, SNMMI 2013-2014 president elect in an exclusive interview to discuss the potential impact of the new climate of coverage in the near to distant future. The CMS coverage decision now allots one amyloid PET scan per patient in approved clinical trials, but it is not yet clear how these studies will proceed. He offers some key points of conversation for stakeholders in dementia imaging.

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Perspectives on Promising Research: What's Next?

There are the workhorses and the newcomers in the world of molecular imaging and biomarkers. What technologies and biomarkers are getting close to entering regular clinical practice? Which ones have a ways to go? Four experts offer thier opinions and rationale.

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The Impact of the Ge-68/Ga-68 on Molecular Imaging

For more than 50 years, speculation has swirled about the tremendous potential of Ga-68 PET imaging to transform molecular imaging. The rapidly increasing number of publications reporting the results of Ga-68 PET imaging studies are evidence that many are working in this direction. 

Amino acid PET tracer tells brain metastases from radiation injury

Delayed brain injury resulting from aggressive radiation treatment can be differentiated from recurrent brain tumors using F-18 FDOPA PET imaging, according to a study published Oct. 28 in the Journal of Nuclear Medicine.

Several new genes found related to Alzheimer's

New research brings 11 new genes into focus as potential links to Alzheimer's and other neurodegenerative diseases including Parkinson's and multiple sclerosis, all associated with the build-up of protein plaques in the brain. The data was made available as a result of the international Genomics of Alzheimer's Project (IGAP), according to an Oct. 28 report by The Huffington Post.

Worldwide PET market expected to grow modestly

The global PET market is set to grow an estimated 3.74 percent from 2012-2016, according to a report published this month by the market research firm Infiniti Research Limited.

Mixed results from phase III flurpiridaz PET trial

Lantheus Medical Imaging has announced preliminary phase III clinical trial results for F-18 flurpiridaz as a diagnostic PET agent for myocardial perfusion imaging indicating high sensitivity but potentially lagging specificity for the detection of CAD.