Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

NHS pushes for major multi-site genomics project

The United Kingdom’s National Health Service (NHS) is embarking on an ambitious gene-sequencing project with 11 genomics institutions in England. The objective is to find targeted treatments for a spectrum of illnesses.

Hedge fund CEO gifts $15M for Alzheimer’s institute

The chief executive officer of Park Avenue hedge fund Third Point, is set to donate $15 million to Mount Sinai Hospital and the Icahn School of Medicine in New York City for a new research institute devoted to studying Alzheimer’s disease.

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Watch neurons fire with fluorescence imaging

Fluorescent lights depict the electrical firing of neurons in the brain in this striking video demonstration reported by Bloomberg. The technology was developed by Adam E. Cohen, PhD, a Harvard neuroscientist and professor of chemical biology and physics.

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Neuroimaging in art

Every week, Molecular Imaging brings hard-hitting neuroimaging research to light, but today we are highlighting the unorthodox work of one neuroscientist—his paintings, in fact, which depict the microstructure of the brain.

Definiens Releases Tissue Studio 4.0 for Quantitative Digital Pathology

Definiens, the global leader in Tissue Phenomics® for oncology diagnostics, today announced the newest version of its leading image analysis software for quantitative digital pathology, Tissue Studio 4.0. The new release provides greater flexibility, more accurate and consistent results, and the ability to use any chromogen for single and dual stain immunohistochemistry (IHC) quantification.

Neuro-inflammation may be intrinsic to autism

Genetic research from John Hopkins and the University of Alabama Birmingham are providing a road map of inflammation linked to autism thanks to a fleet of tissue samples from 72 autistic and healthy brains. Analyses of these tissues showed microglial cells in perpetual hyperdrive, which translates into neuro-inflammation.

Bavarian Nordic Reaches Enrollment Target in the Pivotal Phase 3 Study of PROSTVAC® in Prostate Cancer

Bavarian Nordic A/S (OMX: BAVA, OTC: BVNRY) announced today that it has reached the planned enrollment of 1,200 patients in the PROSPECT Phase 3 clinical study of its targeted active immunotherapy candidate, PROSTVAC®, in the treatment of asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Patients were enrolled at 214 sites in 15 countries.

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Speeding up FDA review for neglected diseases

One of the biggest challenges in medicine today is getting effective diagnostic and therapeutic drugs through the regulatory process unscathed. Judit Rius, the U.S. manager and legal policy adviser for Doctors Without Borders has words of wisdom to share about how to improve FDA reviews and incentives for the development of treatments for much needed drugs, including those for neglected tropical diseases.