Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

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Hunger hormone could signal treatments for Parkinson’s

As Americans anticipate their Thanksgiving dinners, the gnawing sensation of hunger prepares them to eat perhaps too much turkey or pumpkin pie. The same hormone that produces that sensation of hunger could be the secret to a new therapy protecting Parkinson’s patients from disease-related cell death, according to research presented Nov. 16 during the Society of Neuroscience’s annual meeting in Chicago.

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Breast cancer model could usher in new generation of imaging, therapy

A trifecta of cells has been revealed to be the crux of breast cancer metastases. The discovery provides cutting-edge details that could revolutionize the development of diagnostic testing and therapeutic agents for breast cancer, officials at the Albert Einstein College of Medicine in New York announced yesterday.

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Autopsy shows Williams had DLB

The recent death of the beloved comedian and actor Robin Williams by suicide took fans by complete surprise and left many in mourning for the master of improvisation. A recent report in Salon provides details from Williams' autopsy report that indicates the presence of dementia with Lewy bodies (DLB), which may explain some of his uncharacteristic behavior of late. In addition to DLB, Williams also suffered from Parkinson's.

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Novel imaging agent targets pancreatic cancer

MabVax Therapeutic Holdings, in collaboration with the Memorial Sloan Kettering Cancer Center (MSKCC), is presenting an investigational agent for imaging pancreatic cancer and aiding pancreatic tumor resection, MabVax announced Nov. 19.

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The age of theranostic nanoparticles

Over the past several years, theranostic nanoparticle studies have provided several shining examples of where molecular cancer imaging is going. In this review published ahead of print Nov. 20 in the Journal of Nuclear Medicine, researchers discuss the triumphs and tribulations of these tiny yet potent structures.

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Year in Images 2014

This year, Molecular Imaging Insight is not only providing some of the most stunning images from our pages, but also a few research exclusives and offerings from a handful of scientific meetings from around the world, including the Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), the World Molecular Imaging Congress (WMIC) and the European Congress of Radiology (ECR).

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The Evolution of SPECT

The evolution of SPECT imaging has taken many twists and turns as both equipment technology and new radiopharmaceuticals have been developed over the past decade.

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The Business of Molecular Imaging: A Panoply of Challenges

As is true in all clinical disciplines, nuclear medicine practitioners face challenges and obstacles that do not end with procedures and patient care.