Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

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Vizamyl wins European approval

The amyloid PET radiotracer F-18 flutemetamol (Vizamyl) has been given the CE mark from the European Commission authorizing marketing of the drug across Europe, GE Healthcare announced yesterday.

Cancer screening bias casts a shadow on clinical decision making

In the world of cancer screening, there may be a bias of accessibility that is skewed toward more screening when doctors are paid more by Medicaid, according to a study conducted by the division of health services and social policy research at RTI International in Washington, D.C.

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Measuring perfusion defects in SPECT MPI: A quantitative comparison

Three major quantitative softwares offer cardiologists a comprehensive map of myocardial perfusion and function, but they do not always agree, according to a study in the August issue of the Journal of Nuclear Cardiology.

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Quantitative F-18 Flute PET provides more data about brain amyloid

F-18 Flutemetamol (F-18 Flute) alone has been used to procure positive or negative results in visual interpretations of beta-amyloid in the brain as a tool to aid in the diagnosis and study of Alzheimer’s disease. Quantitative analysis could further supercharge this technique by bringing in more data about regional and total tracer uptake, according to a study published Aug. 21 in the Journal of Nuclear Medicine.

Radiant Sage named on CIOReview list of 100 most promising technology companies

Radiant Sage LLC, a provider of on-demand clinical trial imaging infrastructure solutions, today announced that it has been named to CIOReview's list of 100 Most Promising Technology Companies. The CIOReview100 includes companies that are gaining momentum in the technology industry and making an impact.

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Gene therapy acts as a protector against fatal heart condition

A dangerous heart condition associated with muscular dystrophy could one day be treated with a gene therapy that protects the heart under stress. Researchers at the University of Missouri are conducting a preclinical study to develop a gene therapy that could be used for treating other heart conditions, the institution announced last week.

Glioma PET: Radiotracers DOPA and FET go head to head

In a direct visual and quantitative comparison of F-18 FET and F-18 DOPA in primary glioma, FET provided more quantitative characterization, but both were successful for tumor delineation, according to a review published Aug. 14 in the Journal of Nuclear Medicine.

Chronic pain and loss of motivation are chemically intertwined

Chronic pain is associated with a reduction in reward seeking, but not just because people are hurting and do not feel up to the task. New Stanford brain research is providing a more comprehensive picture of how molecular changes in the brain dictate loss of motivation in painful settings.