Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

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Lab on the field: Combining molecular imaging and microfluidics

A tiny molecular imaging system could be used on the field to measure brain injury or in the lab to capture individual molecules that betray the biology of cancer, neurodegenerative diseases such as Alzheimer's and viruses like human immunodeficiency virus (HIV). 

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Playing fluorescent ‘tag’ to study the biology of memory

Never-before-seen preclinical fluorescence imaging has broken new ground in the understanding of how memories are formed by nerve cells in the brain.

Alzheimer’s partnership to fund new research in the United Kingdom

A partnership between the United Kingdom-based Alzheimer’s Society and the Alzheimer’s Drug Discovery Foundation is engaged to fund up to $1.5 million for Alzheimer’s drug development programs.

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Biomedical imaging goes subatomic with advanced electron microscopy

Electron microscopy researchers have been given the Banco Bilbao Vizcaya Argentaria (BBVA) Foundation Frontiers of Knowledge Award for pushing the technology into the picometer range—or one-hundredth the diameter of a hydrogen atom.

SMARTVis improves diagnostics by fusing cardiac CTA and SPECT MPI data

Combining CT angiography (CTA) and SPECT MPI is useful for the evaluation of coronary artery disease (CAD) and shows more diagnostic benefit than just one of the modalities or consecutive use of the two technologies, according to a study published Jan. 1 in the Journal of Nuclear Medicine.

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Molecular breast imaging: a review

Breast-specific imaging systems are by far the most sensitive and specific molecular modalities for the visualization of breast tumors, according to a review published Jan. 16 in the Journal of Nuclear Medicine.

Macrocyclics expands PET applications, serotonin-neurotransmission imaging

New copper-64 and gallium-68 chelating platforms are being developed by Macrocyclics, a subsidiary of AREVA Med, the company announced Jan. 10. Four new formulas would expand the company’s PET imaging portfolio.

Sodium fluoride PET/CT points to plaques, predicts heart attack

A PET/CT study followed 40 sufferers of heart attacks and just as many matched controls imaged with conventional coronary angiography and sodium fluoride PET/CT to gauge vulnerable plaques and see potential risk of heart attack.