Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

Alcoholism pickles the brain by disrupting protein balance

Not only does alcoholism lead to neural atrophy and diminish total brain weight, but it also leads to a dramatic drop in the levels of select proteins in the brain, according to an article published April 3 in PLOS ONE.

Alzheimer's drug patent given the go ahead

Pittsburgh-based pharmaceutical research and development firm Cognition Therapeutics (CogRx) announced April 1 that the company’s patent for numerous drug therapy candidates have been approved.

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A quarter century of cardiovascular risk hastens cognitive decline

Hypertension and other cardiovascular risk factors from early adulthood and beyond have a direct impact on future cognitive ability, according to a study published March 31 in Circulation.

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Beta-amyloid plaque progression is pinned to arterial stiffness

The ongoing deposition of beta-amyloid in the aging brain is related to central arterial stiffness, according to a study published online March 31 in JAMA Neurology.

Y-90 radioembolization effectively treats metastatic breast cancer

Breast cancer metastases that have spread to the liver have been found to be treated successfully with yttrium-90 (Y-90) radioembolization, which led to stabilized disease in 98.5 percent of liver tumors, according to procedings of the Society of Interventional Radiology's 39th Annual Scientific Meeting held March 22-27 in San Diego.

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ABY-025 affibody SPECT highlights HER2 status in breast cancer

First-in-human trial of Indium-111 ABY-025 affibody molecule SPECT imaging safely points out human epidermal growth factor receptor type 2 (HER2) expression in metastatic breast tumors, according to preliminary research published online March 24 in the Journal of Nuclear Medicine.

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Breast imaging with both FDG PET and MR provides additional information

Pretreatment PET with F-18 FDG as well as MR imaging provides useful diagnostic data, with PET showing a particular edge for prognosis, according to a study published online March 24 in the Journal of Nuclear Medicine.

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Lantheus Medical Imaging implicated in $6.2M tax settlement

The office of the New York attorney general, Eric T. Scheiderman, released a statement earlier this month naming Lantheus Medical Imaging and Bristol-Myers Squib in a $6.2 million settlement for failing to pay corporate income taxes in New York.