Imaging Contrast

Contrast agents are injected into patients to help enhance images to make it easier for radiologists distinguish specific areas of the body from surrounding tissues. The most commonly used agents are iodinated contrast dye for computed tomography (CT), interventional cath lab angiography, RF fluoroscopy, and in surgical OR procedures. MRI scans typically use gadolinium-based contrast agents. Ultrasound and echocardiography (cardiac ultrasound) imaging use contrast agents composed of microscopic bubbles to enhance images that otherwise would be suboptimal.

Low dose GBCA effective, safe for pediatric imaging
Although gadopiclenol is approved for adults and children ages 2 and older, there is limited data on its use in the pediatric population.
Bayer seeks FDA approval for gadoquatrane, its latest low-dose GBCA
The investigational agent uses 60% less gadolinium without sacrificing image quality, according to recent clinical trial findings.
FDA approves expanded use of 'powerful' lung imaging tool
The approval will make around 1 million more patients eligible to receive the specialized contrast, which enhances the evaluation of lung ventilation.
Cardiac ultrasound contrast completely safe, despite reports to the contrary
There had been a recent uptick in adverse reactions to contrast agents used in transthoracic or stress echocardiography exams, the findings suggest.
FDA approves popular ultrasound enhancing agent for pediatric patients
Unlike other UEA options, GE HealthCare's Optison does not contain polyethylene glycol. The FDA approved its use for adult patients back in 1997.

Safety of CT contrast agents called into question

Using contrast agents to enhance CT scans is an established risk factor for kidney injury in those at risk for renal complications, according to a March 23 NPR report, but the research that drove that conclusion years ago might be unbalanced.

Imaging contrast allergies are poorly documented in EHRs

Documenting contrast allergies in the electronic health record (EHR) is central for safe imaging, but a new study found such records are incomplete, misleading and often ambiguous. A multidisciplinary approach may be needed to solve the problem.

Ultrasound societies want the FDA to remove contrast label warning

The International Contrast Ultrasound Society (ICUS) is again urging the FDA to remove the “black box” warning from ultrasound contrast agent (UCA) labels, following its filing of a September 2018 citizen petition with the federal agency.

MRI, novel contrast agent improves measurement of brain’s calcium activity

The technique, which combines MRI with a manganese-based contrast agent, could help researchers better understand how neurons communicate in the brain, according to the study published online Feb. 22 in Nature Communications.

Imaging Contrast

Low dose GBCA effective, safe for pediatric imaging

Bayer seeks FDA approval for gadoquatrane, its latest low-dose GBCA

FDA approves expanded use of 'powerful' lung imaging tool

Cardiac ultrasound contrast completely safe, despite reports to the contrary

FDA approves popular ultrasound enhancing agent for pediatric patients