Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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Meta-analysis confirms digoxin is major threat to AF, HF patients

Digoxin, a cardiac glycoside popularly sold under the brand name Lanoxin, poses a major threat to the heart health of atrial fibrillation (AF) and heart failure (HF) patients, according to a review published in the American Journal of Cardiology Oct. 4. Even without confounding conditions, the drug can raise an individual’s risk of all-cause mortality.

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Peripartum cardiomyopathy decreases diastolic function, exercise capacity in long run

Women who suffer from peripartum cardiomyopathy (PPCM) will likely be clinically asymptomatic seven years after they give birth, according to research published in the Journal of the American Heart Association Oct. 3—but it’s also likely they’ll develop enduring diastolic dysfunction and reduced exercise capacity in the same window.

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Functional mitral regurgitation helps predict mortality in HF patients after CRT

Heart failure (HF) patients who experience moderate functional mitral regurgitation (FMR) for at least six months after cardiac resynchronization therapy (CRT) are at an increased risk for death, researchers suggest in a study published this week.

TCT.18: COAPT draws superlatives, raises questions about replicating MitraClip’s benefits

Compared to heart failure patients with severe secondary mitral regurgitation who were treated with guideline-directed medical therapy alone, those randomized to a MitraClip procedure plus optimal medical therapy demonstrated relative reductions of 47 percent for heart failure hospitalizations and 38 percent for mortality at two years of follow-up.

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Long-term alcohol intake linked to poor cardiac remodeling in later years

A Journal of the American College of Cardiology study this week linked long-term alcohol consumption to adverse cardiac remodeling in patients who were initially young and healthy—something the paper’s authors said might be offset by drinking predominantly wine.

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HF patients discharged with euvolemia see fewer readmissions

Heart failure patients who are discharged from the hospital before they reach euvolemia—a healthy balance of blood in the body—are more likely to be readmitted in both the short- and long-term, according to research published in the American Journal of Cardiology this month.

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Hospice in the U.S. remains underutilized, especially among HF patients who need it most

Hospice use in the U.S. has grown to nearly 5 percent among elderly patients with heart failure (HF), according to a JAMA Cardiology study published Aug. 29, but palliative care will likely become increasingly difficult as treatment continues to improve.

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SynCardia defends product after FDA warning about high mortality, stroke risk

Less than two weeks after the FDA sent a warning letter to cardiologists about high mortality and stroke rates associated with SynCardia Systems’ Companion 2 (C2) Driver System, the company has published a response saying pre-implant risk factors were responsible for those outcomes.