Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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Protein could help prevent Duchenne cardiomyopathy

A protein known to protect brain function in the setting of Duchenne muscular dystrophy may also have a positive impact on the heart, according to preliminary research presented at the American Heart Association’s Basic Cardiovascular Sciences scientific sessions on Aug. 1 in San Antonio.

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Researchers propose dynamic waitlist for heart transplantation

Continually updated mortality models based on adverse events and end-organ function are better at showing which transplant candidates most urgently require a new heart, according to a study published in the Journal of the American College of Cardiology.

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Waist measurement could ID patients best suited for heart failure drugs

A simple measure of waist circumference could identify chronic heart failure patients who would benefit most from mineralocorticoid receptor antagonists, according to a review published July 25 in JAMA Cardiology.

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Study offers insight into long-term LVEF trajectories

In following patients with heart failure for up to 15 years, Spanish cardiologists found left ventricular ejection fraction (LVEF) followed an inverse U-shape: LVEF improved for the first year, then plateaued for the rest of the first decade and declined in the following years—especially before death.

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Targeting inflammation in dilated cardiomyopathy leads to ‘striking’ recovery

Italian physicians reported what they believe to be “unprecedented clinical improvement” from interleukin-1 suppression in a patient with dilated cardiomyopathy.

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Cardiac amyloidosis remains underreported in US

Twice as many U.S. deaths due to cardiac amyloidosis were reported in 2015 than in 1979, but a study in JAMA Cardiology suggests the disease remains vastly underdiagnosed.

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Women face greater risk of dying from heart failure

Despite decreases in heart failure (HF) incidence and mortality rates in ambulatory patients, mortality remains higher for women, according to a new study published July 16 in the Canadian Medical Association Journal.

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CD34+ stem cells repair damaged tissue of heart failure patients

Stem cells can be used to “encourage” better function in heart failure (HF) patients in the U.K., according to a recent stem cell therapy trial spearheaded by researchers from the University of Edinburgh. Harvested from bone marrow, the stem cells, which were able to generate new cardiac tissue and blood vessels, had a success rate of 80 percent.