Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Thumbnail

Making history: Lab-grown cardiomyocytes successfully transplanted for 1st time

Lab-growing cardiomyocytes have been transplanted into a human patient for the first time in medical history, according to a report from the Japan Times.

Thumbnail

Cancer drug could be repurposed to treat HFpEF

Scientists have uncovered a potential new treatment for heart failure with preserved ejection fraction (HFpEF)—and it’s one that already exists.

Thumbnail

Study proves diabetes is an independent predictor of HF

A cross-structural analysis published in Mayo Clinic Proceedings this January independently links diabetes to the development of heart failure, suggesting diabetic cardiomyopathy is a real—and growing—issue in the U.S.

Thumbnail

FDA grants dapagliflozin priority review for treatment of HFrEF

Drugmaker AstraZeneca announced Jan. 6 that its SGLT2 inhibitor dapagliflozin, sold commercially as Farxiga, had been granted Priority Review by the FDA for patients with heart failure with reduced ejection fraction.

Thumbnail

Cases of chronic HF expected to reach 32M by 2028

Diagnosed cases of chronic heart failure are expected to number 32 million by 2028, according to a report from analytics company GlobalData.

Thumbnail

Beta-blockers could raise risk of hospitalization for those with ‘stiff heart’ HF

Beta-blocker use was linked to an increased risk of heart failure hospitalizations in a recent study of patients with “stiff heart” HF—a concerning finding considering the majority of such patients take the drugs as part of their care regimen.

Novoheart, AstraZeneca partner to develop HFpEF ‘heart-in-a-jar’

Novoheart, a Vancouver-based stem cell biotech company, is pairing with biopharmaceutical giant AstraZeneca to develop the world’s first human-specific in vitro functional model of heart failure with preserved ejection fraction.

Thumbnail

Brushing teeth frequently may lower risk of AFib, heart failure

Brushing teeth three or more times a day could dramatically lower a person’s risk for CVDs like heart failure and atrial fibrillation, according to preliminary research out of Ewha Womans University in Seoul, South Korea.