Molecular Imaging

Molecular imaging (also called nuclear medicine or nuclear imaging) can image the function of cells inside the body at the molecular level. This includes the imaging modalities of positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) imaging. How does PET and SPECT imaging work? Small amounts of radioactive material (radiopharmaceuticals) injected into a patient. These can use sugars or chemical traits to bond to specific cells. The radioactive material is taken up by cells that consume the sugars. The radiation emitted from inside the body is detected by photon detectors outside the body. Computers take the data to assemble images of the radiation emissions. Nuclear images may appear fuzzy or ghostly rather than the sharper resolution from MRI and CT.  But, it provides metabolic information at a cellular level, showing if there are defects in the function of the heart, areas of very high metabolic activity associated with cancer cells, or areas of inflammation, data not available from other modalities. These noninvasive imaging exams are used to diagnose cancer, heart disease, Alzheimer’s and Parkinson’s disease, bone disorders and other disorders. 

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FDA approves expanded use of PET imaging agent

The product's updated indications include quantification and long-term monitoring of amyloid plaques on imaging.

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'Powerful' new PET agent improves the diagnosis of triple-negative breast cancer

The agent “exhibits powerful tumor delineation” in challenging cases of determining cancer subtypes, and could potentially lead to more personalized, effective treatment strategies. 

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Industry partnership set to advance research on theranostics

The deal will create a Therapy Command Center to support the study and use of theranostics across Massachusetts General Hospital and its affiliated centers in bordering states. 

2025 SNMMI Image of the Year

SNMMI unveils its 2025 Image of the Year

The designation was awarded to a research team from China, who analyzed the efficacy of a novel radiotracer developed to target expression of the PD-L1 protein in suspected head and neck cancers. 

3 industry partnerships, 1 clinical aim: Enriching the global supply chain of medical isotopes

Nuclear medicine operations may soon enjoy steadier flows of certain in-demand radioisotopes. If so, much credit will go to companies that had the strategic sense to collaborate with each other. 

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Tau tangles on PET scans may signal impending cognitive decline in asymptomatic individuals

New data highlight the significance of tau-positive imaging in the progression of Alzheimer’s disease. 

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'Promising' new PET agent for brain metastases put on FDA's Fast Track

Clinical trial results thus far have been promising, representing a significant step forward for the hundreds of thousands of patients affected by brain metastases. 

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Earlier treatment with Pluvicto may be beneficial for patients with hormone-sensitive prostate cancer

The drug has shown a “clinically meaningful benefit” in these patients, suggesting its potential as an earlier treatment option than previously thought, Novartis reports.