Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Dapagliflozin improves outcomes for elderly TAVR patients with heart failure
The positive data were presented as part of a late-breaking clinical trial at ACC.25 in Chicago. One cardiologist on stage for the presentation said these findings will impact the way he manages certain TAVR patients.
FDA approves vutrisiran to treat ATTR-CM
The subcutaneous drug, sold under the brand name Amvuttra, joins an ATTR-CM market that already includes Pfizer’s tafamidis (Vyndaqel, Vyndamax) and BridgeBio’s acoramidis (Attruby).
Direct marketing to cardiologists increases uptake of some, but not all, heart failure drugs
Researchers tracked three years of CMS data to explore how meal-based marketing may influence the habits of general and advanced heart failure cardiologists.
Cannabis use increases risk of heart attack, stroke in young adults
“Asking about cannabis use should be part of clinicians' workup to understand patients' overall cardiovascular risk, similar to asking about smoking cigarettes,” one researcher said. Additional details will be presented at ACC.25 in Chicago.
Patient discharged with total artificial heart for first time—goes 105 days while awaiting transplant
Total artificial heart recipients typically stay in the hospital. In this case, however, the patient was able to wait for a donated heart from the comfort of his own home.

Impella Heart Pump Abiomed RECOVER IV RCT cardiogenic shock

FDA warns Abiomed about ‘significant violations’ related to its Impella heart pumps

The agency said Abiomed did not seek the necessary approvals for one Impella-related device and was slow to act on certain safety concerns.

Endotronix gains key approval from FDA, shares new heart failure data

The company can now begin the enrollment process for its PROACTIVE-HF 2 clinical trial, which will focus on treating patients with NYHA class II heart failure.

CBD could be beneficial for some heart failure patients

The subcutaneous administration of CBD could make a significant impact on patient outcomes, according to new findings presented at the Heart Failure Society of America's annual meeting in Cleveland.

Patisiran, marketed under the name Onpattro

FDA chooses not to approve patisiran for treating ATTR cardiomyopathy

The announcement came just weeks after an FDA subcommittee voted in favor of approval.

What is CKM syndrome? American Heart Association outlines how to identify and manage a dangerous new condition

The American Heart Association has developed an updated strategy for the prevention and management of cardiovascular disease. A newly defined health condition, cardiovascular-kidney-metabolic syndrome, sits at the center of that strategy.

Artificial intelligence (AI) is being developed to help make cardiovascular clinical trials more efficient, lead to faster advances in patient care, and bring possible new treatments to heart patients more quickly. The major cardiac research center of Icahn School of Medicine at Mount Sinai announced today that it signed a memorandum of understanding with the Chiba Institute of Technology (CIT) to collaborate on using AI to enhance cardiovascular disease research.

Mount Sinai partners with the Chiba Institute of Technology on AI to transform cardiovascular research

Agreement aims to use AI to help make cardiology clinical trials more efficient and lead to faster advances in patient care.

AI artificial intelligence stethoscope doctor

FDA clears AI model for detecting signs of heart failure in ECGs

The advanced AI model, developed by Anumana with help from Mayo Clinic, could provide value as a screening tool for heart failure.

cannabis use disorder marijuana joint weed smoking

Excessive cannabis use linked to greater risk of heart attack, other cardiovascular events

Researchers examined data from nearly 60,000 adults, focusing on individuals who have been diagnosed with Cannabis Use Disorder.

Heart Failure

Dapagliflozin improves outcomes for elderly TAVR patients with heart failure

FDA approves vutrisiran to treat ATTR-CM

Direct marketing to cardiologists increases uptake of some, but not all, heart failure drugs

Cannabis use increases risk of heart attack, stroke in young adults

Patient discharged with total artificial heart for first time—goes 105 days while awaiting transplant