Clinical Research

Gene editing software image from Scribe Therapeutics for its STX-1150 drug to treat LDL-C.

Coming soon: First-in-human study of gene-modifying drug for hypercholesterolemia

Gene-editing drugs have shown potential to treat a wide variety of diseases, and this will be one of the first in cardiovascular medicine to begin human trials.

Ryan Madder, MD, Program Director, Interventional Cardiology Fellowship, William Beaumont University Hospital, Corewell Health East, and Michael Abiragi, MD, cardiology fellow, Frederik Meijer Heart and Vascular Institute, Corewell Health West in Grand Rapids, explain a study showing a small number of high dose cases contribute the majority of staff dose, especially STEMI.

STEMI cases bring high doses of radiation to the cath lab

“We're so focused on quickly taking care of the patient ... we may be forgetting about radiation safety,” one researcher explained. 

Routine IR procedure could treat endometriosis.

New oral contrast agent helps spot 'previously impossible-to-detect' findings on CT

Experts involved in its development are confident the agent has the potential to overcome shortcomings associated with conventional oral agents currently on the market. 

doctor looking at CLTI patient's leg

Treating CLTI with atherectomy fails to improve outcomes—is it worth the cost?

Atherectomy is associated with rising healthcare costs, making it important to learn as much about the procedure's long-term value as possible. 

Abbott recently announced it is partnering with AtaCor Medical to develop a next-generation extravascular implantable cardioverter defibrillator (EV-ICD) system. AtaCor's investigational extravascular ICD lead will be paired with Abbott's investigational extravascular ICD system.

Abbott works with AtaCor Medical on extravascular ICD system

Extravascular ICDs were developed to avoid complications such as vascular injuries, lead fractures and lead infections. Although rare, these issues can cause serious, life-threatening complications for patients.

CGuard Prime carotid stent system was cleared by the U.S. Food and Drug Administration (FDA) in June 2025.

Pivotal trial highlights safety, effectiveness of FDA-approved carotid stent

The CGuard Prime carotid stent system from InspireMD was approved by the FDA in 2025. These data confirm the device's ability to reduce a patient's stroke risk during treatment. 

Heart failure experts share guidance on increasing prevention efforts

Cardiology has been shifting from reactionary treatment strategies to a greater emphasis on prevention. This is an especially important trend in heart failure, which is associated with high costs and rising hospitalization rates. 

Novel theranostic shows promise for treating gastric and pancreatic cancer

New theranostic could potentially cure difficult-to-treat gastric and pancreatic cancers

Researchers believe new research findings relating to the PET technique signal its potential “to meaningfully change patient care.”