Clinical

This channel newsfeed includes clinical content on treating patients or the clinical implications in a variety of cardiac subspecialties and disease states. The channel includes news on cardiac surgery, interventional cardiologyheart failure, electrophysiologyhypertension, structural heart disease, use of pharmaceuticals, and COVID-19.   

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FDA takes first step toward ending animal testing as part of ‘3.0 modernization'

Monoclonal antibody therapies will be the first drugs permitted to take advantage of alternatives, including advanced lab simulations and artificial intelligence. A pilot framework to phase out the decades-long requirement for animal testing will be rolled out in the coming year, the FDA said.

"Imaging skins" could improve surgical removal of cancerous tumors.

How 'imaging skins' could improve surgical precision in oncology settings

The novel X-ray detector was designed to be integrated into a custom imaging system that converts radiation into light.

Many older heart failure patients are alone and vulnerable—what can be done to help?

Older heart failure patients with no immediate family are especially vulnerable. Additional interventions may be necessary to reach these patients and provide the best care possible.

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Mediterranean diets that include some lean red meat can still boost cardiovascular health

The study's authors focused on blood pressure reductions and arterial stiffness, sharing their findings in Current Developments in Nutrition.

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Not all radiologists are buying what AI is selling, even when the technology outperforms humans

Providers are up to three times more likely to trust the opinion of humans over AI, even when the algorithm is proven to detect more cancerous lesions than radiologists. 

Raj Makkar, MD, director, interventional cardiology, director, Interventional Cardiology Research Program and professor of medicine, Smidt Heart Institute, Cedars-Sinai Hospital, presented the late-breaking Align-AR clinical trial at ACC 2025 on the first 500 patients treated for aortic regurgitation using the Jena Valve transcatheter aortic valve replacement (TAVR) device.

First 500 patients in Align-AR trial using TAVR for pure aortic regurgitation show strong outcomes

Raj Makkar, MD, Cedars-Sinai, explains the late-breaking data from the Align-AR trial on the first 500 patients treated for aortic regurgitation using the Jena Valve TAVR device.

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How often does mid-treatment imaging change how cancers are managed?

Imaging might not drive as many treatment adjustments as previously believed, according to a new meta-analysis.

The Agitation Solutions Orbis Microbubble Generator simplifies and streamlines the process of saline agitation and delivery for cardiac bubble studies using a single use syringe. It is was cleared for use in Canada in 2024.

Right heart cardiac ultrasound contrast agent for shunts enters U.S. trial

Currently there are no FDA cleared echocardiography contrast agents commercially available for use on the right side of the heart to detect shunts, but a new agent that promises to improve workflow and imaging is about to enter a U.S. trial.