Single injection could help heal heart attack damage

A single injection of saNppa lipid nanoparticles enables self-amplification and high-yield pro-ANP production for more than 28 days. Circulating pro-ANP is selectively cleaved by the cardiac protease corin into active ANP, activating NPR1/cGMP signaling in the heart. Image courtesy of Science, Kaiyue Zhang et al. https://www.science.org/doi/10.1126/science.adu9394

A single injection of saNppa lipid nanoparticles enables self-amplification and high-yield pro-ANP production for more than 28 days. Circulating pro-ANP is selectively cleaved by the cardiac protease corin into active ANP, activating NPR1/cGMP signaling in the heart. Image courtesy of Science, Kaiyue Zhang et al.

Amplifying the body’s natural release of a specific hormone may reduce stress on the heart and limit long‑term damage after myocardial infarctions.