Moderate aortic stenosis linked to a significant risk of death—should earlier interventions be considered?

Large peridevice leaks after left atrial appendage occlusion (LAAO) are incredibly rare and not associated with a greater risk of adverse outcomes, according to new research published in JACC: Clinical Electrophysiology.[1] Smaller residual links are more common, however, and associated with a risk of thromboembolic and bleeding events.

Researchers tracked data from more than 12,000 moderate AS patients who originally participated in one of 25 different studies. While the findings seem to suggest earlier treatment could be beneficial for certain high-risk patients, additional research is still required.