Clinical Research

A single injection of saNppa lipid nanoparticles enables self-amplification and high-yield pro-ANP production for more than 28 days. Circulating pro-ANP is selectively cleaved by the cardiac protease corin into active ANP, activating NPR1/cGMP signaling in the heart. Image courtesy of Science, Kaiyue Zhang et al. https://www.science.org/doi/10.1126/science.adu9394

Single injection could help heal heart attack damage

Amplifying the body’s natural release of a specific hormone may reduce stress on the heart and limit long‑term damage after myocardial infarctions.  

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Researchers develop program that can spot falsified radiology reports written by AI

“With generative AI becoming more capable of producing remarkably convincing radiology reports, there’s a greater risk of fabricated reports being used to falsify medical histories and support fraudulent claims,” the team cautioned.

Several interventional cardiology late-breaking studies were presented at the Cardiovascular Research Technologies (CRT) 2026 meeting March 7-10, and experts from the Society of Society highlighted what they felt was most impactful to clinical practice. Photo by Dave Fornell.

CRT 2026: Key takeaways for interventional cardiologists

CRT studies shed new light on many topics, including long-term TAVR outcomes, radiation protection and advanced interventional techniques.

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High costs may be keeping working-age heart patients from seeking care

When working-age adults develop cardiovascular disease, it often ends up eating up a significant amount of their income. Are insurance companies doing enough to help these patients? 

Angiography demonstrates a high-grade, modestly angulated stenosis (arrow) in the proximal segment of a large diagonal branch (A). Predilation performed with difficulty, and the GEC could not be advanced beyond stenosis even with “inch worming” techniques. (B). Advancement of the CrossFAST (C) beyond the proximal stent edge stenosis (a.), the position of the distal end of the outer catheter (b.), and the microcatheter tip (c.) are indicated.

Next-generation guide extension catheter delivers value during complex PCI

The CrossFAST system was successfully used to deploy multiple stents after other devices fell short. 

heart surgery surgeons

AATS wants to improve research in the field of cardiothoracic surgery

The American Association for Thoracic Surgery has announced a new partnership with the Cardiothoracic Surgical Trials Network. The groups plan on working together to address current challenges in cardiothoracic surgery research.

Newsweek ranked the 50 best heart hospitals in the world

Moderate valve oversizing during TAVR boosts survival—too much may be less beneficial

Oversizing transcatheter heart valves can improve TAVR outcomes. There is still a reason to be cautious, however, especially when patients are receiving a balloon-expandable valve.

Semaglutide, the GLP-1 receptor agonist sold by Novo Nordisk under the brand names Wegovy and Ozempic, is associated with significant health benefits for patients with type 2 diabetes and peripheral artery disease (PAD), according to a late-breaking clinical trial presented at ACC.25, the annual meeting of the American College of Cardiology (ACC).

American College of Cardiology announces late-breaking clinical trials for ACC.26

The American College of Cardiology's 2026 annual meeting will include an all-time record of 60 late-breaking clinical studies.